{"id":2019,"date":"2025-07-09T14:46:39","date_gmt":"2025-07-09T14:46:39","guid":{"rendered":"https:\/\/phoenixlab1.com\/?page_id=2019"},"modified":"2025-07-27T09:34:47","modified_gmt":"2025-07-27T09:34:47","slug":"modelli-preclinici-animali-delle-ibd","status":"publish","type":"page","link":"https:\/\/phoenixlab1.com\/index.php\/modelli-preclinici-animali-delle-ibd\/","title":{"rendered":"Modelli animali delle IBD"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2019\" class=\"elementor elementor-2019\" data-elementor-settings=\"{&quot;element_pack_global_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_padding&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true}}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ed31dc e-con-full e-flex e-con e-parent\" data-id=\"7ed31dc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;https:\\\/\\\/phoenixlab1.com\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Animation.mp4&quot;,&quot;background_video_start&quot;:0,&quot;background_play_on_mobile&quot;:&quot;yes&quot;}\">\n\t\t<div class=\"elementor-background-video-container\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" role=\"presentation\" autoplay muted playsinline loop><\/video>\n\t\t\t\t\t<\/div><div class=\"elementor-element elementor-element-0660f25 e-flex e-con-boxed e-con e-child\" data-id=\"0660f25\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-faf40ce elementor-widget elementor-widget-heading\" data-id=\"faf40ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">MODELLI ANIMALI DELLE IBD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6c452e4 e-flex e-con-boxed e-con e-parent\" data-id=\"6c452e4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f945ced elementor-widget elementor-widget-spacer\" data-id=\"f945ced\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b80d625 elementor-widget elementor-widget-heading\" data-id=\"b80d625\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L'IMPORTANZA DEI MODELLI ANIMALI NELLA RICERCA PRECLINICA SULLE IBD***<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f3b4bb elementor-widget elementor-widget-text-editor\" data-id=\"4f3b4bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Le malattie infiammatorie intestinali (<span style=\"color: #cfaf7a; font-weight: bold;\">IBD<\/span>), come il\u00a0<span style=\"color: #cfaf7a; font-weight: bold;\">morbo di Crohn<\/span>\u00a0e la\u00a0<span style=\"color: #cfaf7a; font-weight: bold;\">colite ulcerosa<\/span> colpiscono milioni di persone in tutto il mondo e, ad oggi, non esiste ancora una cura definitiva. Molti trattamenti sono stati testati, ma solo pochi sono arrivati fino alla clinica. Per sviluppare terapie pi\u00f9 efficaci e sicure, <span style=\"color: #cfaf7a; font-weight: bold;\">i modelli sperimentali su topo, possono offrire informazioni preziose e accelerare la ricerca verso nuove soluzioni<\/span>.<\/span><\/p><p>Grazie alla possibilit\u00e0 di riprodurre in modo controllato i meccanismi patologici tipici dell\u2019infiammazione intestinale, questi modelli permettono di:<\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83e\uddec <\/span><b style=\"color: #cfaf7a;\">&#8211; Comprendere le basi immunologiche e molecolari<\/b><span style=\"font-weight: 400;\"> delle IBD<\/span><\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83e\uddea <\/span><b style=\"color: #cfaf7a;\">&#8211; Valutare l\u2019efficacia e la sicurezza<\/b><span style=\"font-weight: 400;\"> di nuovi candidati farmaci<\/span><\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83d\udd2c <\/span><b style=\"color: #cfaf7a;\">&#8211; Esplorare biomarcatori predittivi e target terapeutici<\/b><\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83d\udc89 <\/span><b style=\"color: #cfaf7a;\">&#8211; Ottimizzare strategie di somministrazione e combinazioni terapeutiche<\/b><\/p><p><span style=\"font-weight: 400;\">Attraverso l\u2019uso di modelli murini e translazionali validati, \u00e8 possibile simulare diversi fenotipi e stadi della malattia, riflettendo l\u2019eterogeneit\u00e0 clinica osservata nei pazienti.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\">Negli studi di efficacia terapeutica di un farmaco in via di svulippo, la scelta del modello murino pi\u00f9 adatto dipender\u00e0 da tanti fattori, che includono il meccanismo di azione del farmaco e il suo target cellulare.\u00a0<\/span><\/p><p><b>Grazie all\u2019esperienza del nostro team, selezioniamo i modelli preclinici pi\u00f9 idonei al tuo obiettivo terapeutico, garantendo risultati rilevanti e traslabili alle IBD nell\u2019 uomo.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3565ce1 elementor-widget elementor-widget-text-editor\" data-id=\"3565ce1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I nostri modelli murini delle IBD:<\/p><p>1)\u00a0<a style=\"color: #cfaf7a;\" href=\"https:\/\/phoenixlab1.com\/index.php\/modello-acuto-e-cronico-indotto-dal-dextran-sulfate-sodium-dss\/\" rel=\"noopener\">Modello acuto e cronico indotto dal Dextran sulfate sodium (DSS)<\/a><br \/>2)\u00a0<a style=\"color: #cfaf7a;\" href=\"https:\/\/phoenixlab1.com\/index.php\/modello-acuto-e-cronico-indotto-dal-trinitrobenzenesulfonic-acid-tnbs\/\" rel=\"noopener\">Modello acuto e cronico indotto dal Trinitrobenzenesulfonic acid (TNBS)<\/a><br \/>3)\u00a0<a style=\"color: #cfaf7a;\" href=\"https:\/\/phoenixlab1.com\/index.php\/modello-di-colite-indotto-da-cellule-t\/\" rel=\"noopener\">Modello di colite indotto da cellule T<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-544bafb elementor-widget elementor-widget-spacer\" data-id=\"544bafb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16bd63e elementor-widget elementor-widget-text-editor\" data-id=\"16bd63e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">***NOTA: Tutte le procedure sperimentali sugli animali sono eseguite in conformit\u00e0 con la Direttiva 2010\/63\/UE e il D.Lgs. 26\/2014, che regolano la protezione degli animali utilizzati a fini scientifici. Ogni protocollo \u00e8 sottoposto a valutazione e approvazione da parte dell\u2019<\/span><b>Organismo Preposto al Benessere degli Animali (OPBA)<\/b><span style=\"font-weight: 400;\"> e successivamente autorizzato dal <\/span><b>Ministero della Salute<\/b><span style=\"font-weight: 400;\">, secondo quanto previsto dalle normative nazionali ed europee. I nostri studi seguono rigorosamente i principi delle <\/span><b>3R (Replacement, Reduction, Refinement)<\/b><span style=\"font-weight: 400;\"> per garantire un uso etico e scientificamente giustificato dei modelli animali.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>MODELLI ANIMALI DELLE IBD L&#8217;IMPORTANZA DEI MODELLI ANIMALI NELLA RICERCA PRECLINICA SULLE IBD*** Le malattie infiammatorie intestinali (IBD), come il\u00a0morbo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2019","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages\/2019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/comments?post=2019"}],"version-history":[{"count":72,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages\/2019\/revisions"}],"predecessor-version":[{"id":2743,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages\/2019\/revisions\/2743"}],"wp:attachment":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/media?parent=2019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}