{"id":2791,"date":"2025-07-27T10:25:31","date_gmt":"2025-07-27T10:25:31","guid":{"rendered":"https:\/\/phoenixlab1.com\/?page_id=2791"},"modified":"2025-07-27T17:56:28","modified_gmt":"2025-07-27T17:56:28","slug":"animal-models-of-ibd","status":"publish","type":"page","link":"https:\/\/phoenixlab1.com\/index.php\/en\/animal-models-of-ibd\/","title":{"rendered":"Animal models of IBD"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2791\" class=\"elementor elementor-2791\" data-elementor-settings=\"{&quot;element_pack_global_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_padding&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true}}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ed31dc e-con-full e-flex e-con e-parent\" data-id=\"7ed31dc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;https:\\\/\\\/phoenixlab1.com\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Animation.mp4&quot;,&quot;background_video_start&quot;:0,&quot;background_play_on_mobile&quot;:&quot;yes&quot;}\">\n\t\t<div class=\"elementor-background-video-container\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" role=\"presentation\" autoplay muted playsinline loop><\/video>\n\t\t\t\t\t<\/div><div class=\"elementor-element elementor-element-0660f25 e-flex e-con-boxed e-con e-child\" data-id=\"0660f25\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-faf40ce elementor-widget elementor-widget-heading\" data-id=\"faf40ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">ANIMAL MODELS OF IBD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6c452e4 e-flex e-con-boxed e-con e-parent\" data-id=\"6c452e4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f945ced elementor-widget elementor-widget-spacer\" data-id=\"f945ced\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b80d625 elementor-widget elementor-widget-heading\" data-id=\"b80d625\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">THE IMPORTANCE OF ANIMAL MODELS IN PRECLINICAL RESEARCH ON IBD***<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f3b4bb elementor-widget elementor-widget-text-editor\" data-id=\"4f3b4bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Inflammatory bowel diseases (<span style=\"color: #cfaf7a; font-weight: bold;\">IBD<\/span>), such as <span style=\"color: #cfaf7a; font-weight: bold;\">Crohn\u2019s disease<\/span> and <span style=\"color: #cfaf7a; font-weight: bold;\">ulcerative colitis<\/span>, affect millions of people worldwide and, to date, no definitive cure exists. Many treatments have been tested, but only a few have reached the clinic. To develop more effective and safer therapies, <span style=\"color: #cfaf7a; font-weight: bold;\">experimental mouse models can provide valuable insights and accelerate research toward new solutions<\/span>.<\/span><\/p><p>Thanks to their ability to reproducibly simulate the pathological mechanisms typical of intestinal inflammation, these models allow us to:<\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83e\uddec <\/span><b style=\"color: #cfaf7a;\">&#8211; Understand the immunological and molecular basis<\/b><span style=\"font-weight: 400;\"> of IBD<\/span><\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83e\uddea <\/span><b style=\"color: #cfaf7a;\">&#8211; Assess the efficacy and safety<\/b><span style=\"font-weight: 400;\"> of new drug candidates<\/span><\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83d\udd2c <\/span><b style=\"color: #cfaf7a;\">&#8211; Explore predictive biomarkers and therapeutic targets<\/b><\/p><p><span style=\"font-weight: 400; font-size: 50px;\">\u00a0 \u00a0 \ud83d\udc89 <\/span><b style=\"color: #cfaf7a;\">&#8211; Optimize administration strategies and therapeutic combinations<\/b><\/p><p><span style=\"font-weight: 400;\">Through the use of validated murine and translational models, it is possible to simulate different phenotypes and stages of the disease, reflecting the clinical heterogeneity observed in patients.<\/span><\/p><p><span style=\"font-weight: 400;\">In therapeutic efficacy studies of a drug under development, choosing the most suitable murine model depends on many factors, including the drug\u2019s mechanism of action and cellular target.<\/span><\/p><p><b>Thanks to our team\u2019s expertise, we select the most appropriate preclinical models for your therapeutic goal, ensuring relevant and translatable results for IBD in humans.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3565ce1 elementor-widget elementor-widget-text-editor\" data-id=\"3565ce1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our murine models of IBD:<\/p><p>1) <a style=\"color: #cfaf7a;\" href=\"https:\/\/phoenixlab1.com\/index.php\/en\/acute-and-chronic-model-induced-by-dextran-sulfate-sodium-dss\/\" rel=\"noopener\">Acute and chronic model induced by Dextran Sulfate Sodium (DSS)<\/a><br \/>2) <a style=\"color: #cfaf7a;\" href=\"https:\/\/phoenixlab1.com\/index.php\/en\/acute-and-chronic-model-induced-by-trinitrobenzenesulfonic-acid-tnbs\/\" rel=\"noopener\">Acute and chronic model induced by Trinitrobenzenesulfonic Acid (TNBS)<\/a><br \/>3) <a style=\"color: #cfaf7a;\" href=\"https:\/\/phoenixlab1.com\/index.php\/en\/t-cell-induced-colitis-model\/\" rel=\"noopener\">T cell-induced colitis model<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-544bafb elementor-widget elementor-widget-spacer\" data-id=\"544bafb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16bd63e elementor-widget elementor-widget-text-editor\" data-id=\"16bd63e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">***NOTE: All experimental procedures involving animals are carried out in compliance with Directive 2010\/63\/EU and Legislative Decree 26\/2014, which govern the protection of animals used for scientific purposes. Every protocol is evaluated and approved by the <\/span><b>Animal Welfare Body (OPBA)<\/b><span style=\"font-weight: 400;\"> and subsequently authorized by the <\/span><b>Ministry of Health<\/b><span style=\"font-weight: 400;\">, in accordance with national and European regulations. Our studies strictly follow the principles of the <\/span><b>3Rs (Replacement, Reduction, Refinement)<\/b><span style=\"font-weight: 400;\"> to ensure the ethical and scientifically justified use of animal models.<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>ANIMAL MODELS OF IBD THE IMPORTANCE OF ANIMAL MODELS IN PRECLINICAL RESEARCH ON IBD*** Inflammatory bowel diseases (IBD), such as [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2791","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages\/2791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/comments?post=2791"}],"version-history":[{"count":7,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages\/2791\/revisions"}],"predecessor-version":[{"id":2881,"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/pages\/2791\/revisions\/2881"}],"wp:attachment":[{"href":"https:\/\/phoenixlab1.com\/index.php\/wp-json\/wp\/v2\/media?parent=2791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}